Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma

Background/Aim: Maspin has tumor-suppressor functions; however, its prognostic value in patients with oral squamous cell carcinoma (OSCC) remains unknown. We aimed to assess the importance of subcellular localization maspin OSCC. Patients and Methods: Eighty resected specimens were analyzed by immunohistochemistry. Cytoplasmic-only expression observed >10% tumor was defined as maspin-positive. Results: The maspin-positive status (25%) significantly associated a higher recurrence rate shorter disease-free survival (DFS). Cox’s multivariate analysis showed that an independent factor for DFS. All OSCC lines (HSC2, HSC3, HSC4, Ca9-22 SAS) protein both cytoplasm nucleus using western blot analysis. In HSC4 cells, invasion increased response knockdown. Conclusion: could be poor